خرید و دانلود کتاب
Pathways to Pregnancy and Parturition 2nd Edition
Regulatory nuclear pathways feeding into the transcription of cancer-relevant
molecules have emerged as the next frontier in pathway-centered cancer therapeutics.
The signifi cance of nuclear signaling in cancer is also evident by the convergence of
a large number of signal transduction pathways continuously sensing extracellular
milieu. The cumulative outcome of deregulated cytoplasmic and nuclear signaling
is to provide a favorable environment for a cancer cell to survive by overriding death
signals, to sustain an excessive hyper-mitogenic activity, to feed into deregulated
cell cycle progression, and to support a defective segregation of genetic material
during mitosis leading to genomic instability, to name a few essential hallmarks of
cancer progression. Among other processes, chromatin remodeling and epigenetic
modifi cations are two important nuclear regulatory arms of transcription that have
offered a battery of exciting therapeutic opportunities in terms of specifi city by
focusing on specifi c modifi cation or modifi cations of histone or nonhistone pro-
teins, domain-targeting, enzymatic activities such as histone deacetylases, histone
acetyltransferases, histone demethylases, or splicing factors – as all of these activi-
ties are widely deregulated in multiple human cancers. A large body of work during
the last decade has demonstrated that these are targetable areas of translational can-
cer medicine, and therefore, a large number of small molecules or agents targeting
these biological processes are rapidly moving through the preclinical development
pipeline to clinical studies.
